Repolarization of Immunosuppressive Macrophages by Targeting SLAMF7-Regulated CCL2 Signaling Sensitizes Hepatocellular Carcinoma to Immunotherapy.

Jialei Weng Zheng Wang Zhi-Qiu Hu Wenxin Xu Jia-Lei Sun Fu Wang Qiang Zhou Shaoqing Liu Min Xu Ming-Hao Xu Dongmei Gao Ying-Hao Shen Yong Yi Yi Shi Qiong-Zhu Dong Chenhao Zhou Ning Ren

Published in: Cancer research (2024)

CCL2 upregulation caused by SLAMF7 deficiency in hepatocellular carcinoma cells induces immunosuppressive macrophage polarization and confers resistance to immune checkpoint blockade, providing potential biomarkers and targets to improve immunotherapy response in patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
liver fibrosis
prognostic factors
peritoneal dialysis
transcription factor
cell proliferation
signaling pathway
oxidative stress
patient reported outcomes
patient reported
smoking cessation
drug induced