Pituitary macroadenomas in childhood and adolescence: a clinical analysis of 7 patients.

Cristina Aguilar-RieraMaría ClementeNúria González-LlorensEduard MogasAriadna Campos-MartorellAnna FàbregasBetina BiagettiElida VázquezDiego Yeste

Published in: Clinical diabetes and endocrinology (2023)

Pediatric pituitary macroadenomas are a distinct entity, mostly found in males and with a predominance of functional tumors leading to detrimental effects on growth and puberty in addition to neuro-ophthalmological manifestations. It is important to perform genetic studies in patients with macroadenomas appearing under the age of 18 years as genetic and syndromic associations are more frequent in this age group.

Keyphrases

genome wide
growth hormone
depressive symptoms
copy number
intellectual disability
gene expression
childhood cancer
early life