Glucosamine-Mediated Hexosamine Biosynthesis Pathway Activation Uses ATF4 to Promote "Exercise-Like" Angiogenesis and Perfusion Recovery in PAD.

Suhib AlhusbanMohamed NofalAnita Kovacs-Kasa Taylor C KressM Murat KoseogluAbdelrahman A Zaied Eric J Belin de Chantemèle Brian H Annex

Published in: Circulation (2024)

In cells, mice, and humans, activation of hexosamine biosynthesis pathway by glucosamine in peripheral arterial disease induces an "exercise-like" angiogenesis and offers a promising novel therapeutic pathway to treat this challenging disorder.

Keyphrases

high intensity
endothelial cells
induced apoptosis
vascular endothelial growth factor
endoplasmic reticulum stress
transcription factor
type diabetes
resistance training
cell cycle arrest
magnetic resonance
oxidative stress
computed tomography
wound healing
signaling pathway
insulin resistance