Concomitant Brain Injury and Spinal Cord Injury Management Strategies: A Narrative Review.
Adriana D Valbuena ValecillosDavid R GaterGemayaret AlvarezPublished in: Journal of personalized medicine (2022)
Spinal cord injury (SCI) is a catastrophic event with multiple comorbidities including spastic paralysis, sensory loss, autonomic dysfunction with sympathetic blunting, neurogenic orthostatic hypotension, neurogenic restrictive and obstructive lung disease, neuropathic pain, spasticity, neurogenic bladder, neurogenic bowel, immobilization hypercalcemia, osteopenia/osteoporosis, neurogenic obesity, and metabolic dysfunction. Cervical and thoracic SCI is all too often accompanied by traumatic brain injury (TBI), which carries its own set of comorbidities including headaches, seizures, paroxysmal sympathetic hyperactivity, aphasia, dysphagia, cognitive dysfunction, memory loss, agitation/anxiety, spasticity, bladder and bowel incontinence, and heterotopic ossification. This manuscript will review the etiology and epidemiology of dual diagnoses, assessment of both entities, and discuss some of the most common comorbidities and management strategies to optimize functional recovery.
Keyphrases
- spinal cord injury
- neuropathic pain
- brain injury
- spinal cord
- traumatic brain injury
- subarachnoid hemorrhage
- metabolic syndrome
- oxidative stress
- type diabetes
- insulin resistance
- weight loss
- heart rate variability
- postmenopausal women
- botulinum toxin
- atrial fibrillation
- bone mineral density
- depressive symptoms
- heart rate
- adipose tissue
- body mass index
- high fat diet induced