Apoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway.

Xiaotong HuangXiaoxing KouTing ZhanGuokun WeiFeinan HeXueli MaoHaidi Yang

Published in: Stem cell research & therapy (2023)

These findings uncovered the role of apoVs in preventing NIHL and resisting oxidative damage, indicating that apoVs is a promising way for inner ear delivery and a prospective cell-free therapy for NIHL.

Keyphrases

cell free
hearing loss
high glucose
cell death
diabetic rats
circulating tumor
transcription factor
air pollution
signaling pathway
drug induced
endothelial cells
pi k akt
oxidative stress
anti inflammatory