A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer.
Emanuela DylgjeriVishal KothariAyesha A ShafiGalina SemenovaPeter T GallagherYi F GuanAngel PangJonathan F GoodwinSwati IraniJennifer J McCannAmy C MandigoSaswati N ChandChristopher M McNairIrina A VasilevskayaMatthew J SchiewerCostas D LallasPeter A McCueLeonard G GomellaErin L SeifertJason S CarrollLisa M ButlerJeff HolstWilliam K KellyKaren E KnudsenPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Findings herein unveil novel DNA-PK partners, substrates, and function in prostate cancer. DNA-PK impacts glycolysis through direct interaction with glycolytic enzymes and modulation of enzymatic activity. These events support energy production that may contribute to generation and/or maintenance of DNA-PK-mediated aggressive disease phenotypes.