Long-term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T-cells, IL-10 and TGF-β, in dogs with atopic dermatitis.
Ina HerrmannLisa B MamoJenny HolmesJavid P MohammedK Marcia MurphyPetra BizikovaPublished in: Veterinary dermatology (2022)
Lower Treg cell percentages in the CSA-treated dogs suggest an impact of this drug on this cell population; however, it does not necessarily mean that it diminishes tolerance. Functionality and cytokine production may be more important than the number of Treg cells. Further studies evaluating the treatment outcome of dogs receiving AIT and concurrent drugs are needed to show clinical relevance.
Keyphrases
- regulatory t cells
- single cell
- atopic dermatitis
- cell therapy
- induced apoptosis
- dendritic cells
- stem cells
- cell cycle arrest
- squamous cell carcinoma
- cell proliferation
- emergency department
- cell death
- signaling pathway
- oxidative stress
- immune response
- mesenchymal stem cells
- endoplasmic reticulum stress
- locally advanced