Cerebellar connectome alterations and associated genetic signatures in multiple sclerosis and neuromyelitis optica spectrum disorder.

Yuping YangJunle LiTing LiZhen LiZhizheng ZhuoXuemei HanYunyun DuanGuanmei CaoFenglian ZhengDecai TianXinli WangXinghu ZhangKuncheng LiFuqing ZhouMuhua HuangYuxin LiHaiqing LiYongmei LiChun ZengNingnannan ZhangJie SunChunshui YuFudong ShiUmer AsgherNils MuhlertYaou LiuJingxuan Ruan

Published in: Journal of translational medicine (2023)

We demonstrate convergent and divergent cerebellar connectome alterations and associated transcriptomic signatures between MS and NMOSD, providing insight into shared and unique neurobiological mechanisms underlying these two diseases.

Keyphrases

multiple sclerosis
spectrum disorder
genome wide
resting state
mass spectrometry
white matter
ms ms
single cell
dna methylation
copy number
rna seq