Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder.
Jonathan D SantoroRebecca PartridgeRuni TannaDania PagarkarMellad KhoshnoodMustafa RehmaniRyan M KammeyerGrace Y GombolayKristen FisherAllison ConraveyJane El-DahrAlison L ChristyLina PatelMelanie A ManningHeather Van MaterMichael S RafiiEileen A QuinnPublished in: Journal of neurodevelopmental disorders (2022)
This study reports the novel presence of neurodiagnostic testing abnormalities in individuals with Down syndrome regression disorder, providing credence to this symptom cluster potentially being of neurologic and/or neuroimmunologic etiology.