Genes identified in rodent studies of alcohol intake are enriched for heritability of human substance use.
Spencer B HuggettEmma C JohnsonAlexander S HatoumDongbing LaiJenani SrijeyanthanJason A BubierElissa J CheslerArpana AgrawalAbraham A PalmerHoward J EdenbergRohan H C PalmerPublished in: Alcoholism, clinical and experimental research (2021)
Our results suggest that rodent gene expression studies can help to identify genes that contribute to heritability of some substance use traits in humans, yet there was less specificity than expected. We outline various limitations, interpretations and considerations for future research.