Studies toward the Total Syntheses of Calyciphylline D-Type Daphniphyllum Alkaloids.
Yi CuiJun RenJiayuan LvZhong-Wen WangPublished in: Organic letters (2021)
An efficient construction of an aza-[5.7.6.5] tetracyclic core structure of calyciphylline D-type Daphniphyllum alkaloids has been achieved. The synthetic route features a diastereoselective cyclopropanation, efficient construction of the core bridged 8-aza-[3.2.1]octane skeleton through a [3 + 2] IMCC strategy, oxidative dearomatization of phenol, and gram-scale preparation in each step.