AI-based AlphaFold2 significantly expands the structural space of the autophagy pathway.

Nidhi MalhotraShantanu KhatriAjit KumarAkanksha ArunPurba DaripaSaman FatihiSureshkumar VenkadesanNiyati JainLipi Thukral

Published in: Autophagy (2023)

AF2: AlphaFold2; AF2-Mult: AlphaFold2 multimer; ATG: autophagy-related; CTD: C-terminal domain; ECTD: extreme C-terminal domain; FR: flexible region; MD: molecular dynamics; NTD: N-terminal domain; pLDDT: predicted local distance difference test; UBL: ubiquitin-like.

Keyphrases

molecular dynamics
cell death
density functional theory
atrial fibrillation
endoplasmic reticulum stress
signaling pathway
oxidative stress
climate change
small molecule