Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.

Jiecan Zhou Bo XuFazhong HeYan ShuXiaoping ChenZhaoqian LiuBao SunWei Zhang

Published in: Cardiovascular diabetology (2024)

We found that patients with G allele of RASGRP1 (rs56254815) showed a better antihypertensive therapy efficacy in T2DM patients. The rs7403531 T allele could reduce the risk of major microvascular events and major eye diseases in T2DM patients receiving either hypoglycemic or antihypertensive therapy. Our findings suggest that RASGRP1 genetic polymorphism might predict the cardiovascular complications in T2DM patients.

Keyphrases

glycemic control
end stage renal disease
blood pressure
type diabetes
newly diagnosed
chronic kidney disease
prognostic factors
stem cells
risk factors
gene expression
metabolic syndrome
patient reported outcomes
hypertensive patients
insulin resistance
patient reported
mesenchymal stem cells
smoking cessation