α-Particle-induced DNA damage tracks in peripheral blood mononuclear cells of [223Ra]RaCl2-treated prostate cancer patients.

Sarah SchumannU EberleinC LapaJ MüllerS SerflingM LassmannH Scherthan

Published in: European journal of nuclear medicine and molecular imaging (2021)

The γ-H2AX+53BP1 assay is a potent method for detection of α-particle-induced DNA damages during treatment with or after accidental incorporation of radionuclides even at low absorbed doses. It may serve as a biomarker discriminating α- from β-emitters based on damage geometry.

Keyphrases

dna damage
diabetic rats
high glucose
oxidative stress
prostate cancer
rheumatoid arthritis
drug induced
dna repair
circulating tumor
disease activity
ankylosing spondylitis
benign prostatic hyperplasia
sensitive detection