Late-stage sequela of an isolated optic neuropathy after acute magnesium valproate overdose: A case report.
Xuhao ChenHaohao DiYing HongChun ZhangPublished in: European journal of ophthalmology (2020)
We report a rare case of TON caused by acute VPA overdose. Hyperbaric oxygen therapy, and neuroprotective and neurotrophic treatments might be effective at the early stage but cannot fully reverse the damage to the optic nerve. The present case indicates the potential neurotoxicity of VPA. It is crucial to determine the severity of an isolated optic nerve sequela caused by VPA overdose, though it might be rare as observed in previous reports. Further confirmation of the likelihood of its causation and its pathophysiology is needed in the future.
Keyphrases
- optic nerve
- rare case
- early stage
- optical coherence tomography
- liver failure
- oxidative stress
- respiratory failure
- squamous cell carcinoma
- drug induced
- stem cells
- mesenchymal stem cells
- blood brain barrier
- lymph node
- brain injury
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- locally advanced
- mechanical ventilation