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Quality evaluation of the Azithromycin tablets commonly marketed in Adama, and Modjo towns, Oromia Regional State, Ethiopia.

Yesuneh Tefera MekashaBelachew Umeta ChaliAnbessa Bekele FeissaGemmechu Hasen GodenaHassen Kebede HassenSultan Suleman Wega
Published in: PloS one (2023)
All of the evaluated brands passed the quality specification. The model dependent approaches revealed that drug release data fit well to the Weibull, and Korsemeyer's Peppas release models. However, the model-independent parameters have confirmed that only two brands were deemed better brands (2/6) for interchangeability. Due to the dynamic nature of low-quality medications, the Ethiopian Food, and Drug Authority should keep an eye on marketed products to guarantee their quality, especially for drugs like azithromycin for which non-bioequivalence data from the study has revealed a clinical concern.
Keyphrases
  • drug release
  • quality improvement
  • electronic health record
  • single cell
  • big data
  • machine learning
  • deep learning