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Pathogenic role of 25-hydroxycholesterol in cancer development and progression.

Sura Salman EjamRaed Obaid SalehMaria Jade Catalan OpulenciaMazin Aa NajmAziza MakhmudovaAbduladheem Turki JalilWalid Kamal AbdelbassetMoaed E Al-GazallyAli Thaeer HammidYasser Fakri MustafaSergushina Elena SergeevnaSajad KarampoorRasoul Mirzaei
Published in: Future oncology (London, England) (2023)
Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol (25-HC) is a cholesterol derivative that may be formed from cholesterol. 25-HC is a crucial component in various biological activities, including cholesterol metabolism. In recent years, growing evidence has shown that 25-HC performs a critical function in the etiology of cancer, infectious diseases and autoimmune disorders. This review will summarize the latest findings regarding 25-HC, including its biogenesis, immunomodulatory properties and role in innate/adaptive immunity, inflammation and the development of various types of cancer.
Keyphrases
  • papillary thyroid
  • low density lipoprotein
  • squamous cell
  • immune response
  • multiple sclerosis
  • induced apoptosis
  • lymph node metastasis
  • young adults
  • childhood cancer
  • cell proliferation
  • cell death