Urinary tubular biomarkers as predictors of death in critically ill patients with COVID-19.
Gabriela Freire BezerraGdayllon Cavalcante MenesesPolianna Lemos Moura Moreira AlbuquerqueNicole Coelho LopesRanieri Ss SantosJuliana C da SilvaSandra Mara Brasileiro MotaRodrigo R GuimarãesFábio R GuimarãesÁlvaro Rolim GuimarãesCaio Manuel Caetano AdamianPaula Roberta de LimaIzabel Cj BandeiraMárcia Mp DantasGeraldo Bezerra da Silva JúniorReinaldo Barreto OriáElizabeth de Francesco DaherAlice Maria Costa MartinsPublished in: Biomarkers in medicine (2022)
Aim: To evaluate the prediction capacity of urinary biomarkers for death in critically ill patients with COVID-19. Methods: This is a prospective study with critically ill patients due to COVID-19 infection. The urinary biomarkers NGAL, KIM-1, MCP-1 and nephrin were quantified on ICU admission. Results: There was 40% of death. Urinary nephrin and MCP-1 had no association with death. Tubular biomarkers (proteinuria, NGAL and KIM-1) were predictors of death and cut-off values of them for death were useful in stratify patients with worse prognosis. In a multivariate cox regression analysis, only NGAL remains associated with a two-mount survival chance. Conclusion: Kidney tubular biomarkers, mostly urinary NGAL, had useful capacity to predict death in critically ill COVID-19 patients.