Efficacy and safety of biologic agents for the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials.

Fanqiang MengHui LiHaoran FengHuizhong LongZidan YangJiatian LiYuqing WangDongxing Xie

Published in: Therapeutic advances in musculoskeletal disease (2022)

The efficacy and safety of biologic agents vary by mechanism of action. NGF inhibitors can relieve OA-related pain and improve function but involve safety concerns. IL-1 inhibitors and TNF-α inhibitors are relatively safe options but with limited efficacy.

Keyphrases

rheumatoid arthritis
placebo controlled
double blind
phase iii
chronic pain
knee osteoarthritis
phase ii
open label
clinical trial
pain management
neuropathic pain
growth factor
spinal cord
radiation therapy
smoking cessation