Genomic Characterization of a Dog-Mediated Rabies Outbreak in El Pedregal, Arequipa, Peru.

Renzo S Salazar Sanchez Kirstyn BrunkerElvis W DíazEdith ZegarraYnes MonroyGorky N BaldarragoKatty Borrini-MayoríMichaela De la Puente-LeónSandeep KasaragodMichael Z LevyKatie HampsonRicardo Castillo-Neyra

Published in: bioRxiv : the preprint server for biology (2024)

Genomic insights into the El Pedregal outbreak revealed multiple introductions over a 2-year window. Eco-epidemiological conditions, including migratory worker patterns, suggest human-mediated movement drove introductions. Despite outbreak containment, El Pedregal remains at risk of dog-mediated rabies due to ongoing circulation in Arequipa, Puno, and Bolivia. Human-mediated movement of dogs presents a major risk for rabies re-emergence in Peru, jeopardizing regional dog-mediated rabies control. Additional sequence data is needed for comprehensive phylogenetic analyses.

Keyphrases

endothelial cells
machine learning
electronic health record
big data
single cell
deep learning