Ganab Haploinsufficiency Does Not Cause Polycystic Kidney Disease or Polycystic Liver Disease in Mice.

Guangrui Geng Yunming XiaoYingjie ZhangWanjun ShenJiaona LiuFei ZhuXu WangJie WuRan LiuGuang-Yan Cai Xue-Yuan Bai Qinggang Li Xiang-Mei Chen

Published in: BioMed research international (2020)

Homozygous Ganab mutations are lethal in the fetal stage, and Ganab haploinsufficiency does not cause kidney or liver cysts in mice, suggesting that it may not be the causative gene in polycystic kidney disease.

Keyphrases

polycystic kidney disease
high fat diet induced
genome wide
wild type
copy number
type diabetes
insulin resistance
adipose tissue
dna methylation