Genetically downregulated Interleukin-6 signalling is associated with a lower risk of frailty.

Niki MourtziMariosk GeorgakisEva NtanasiAlexandros HatzimanolisAlfredo RamirezStephanie Heilmann-HeimbachBenjamin Grenier-BoleyJeanc LambertMary YannakouliaMary KosmidisEfthimios DardiotisGiorgos HadjigeorgiouParaskevi SakkaNikolaos Scarmeas

Published in: Age and ageing (2023)

our results support a potential causal effect of IL-6 signalling on frailty and further suggest that downregulation of IL-6 levels may reduce frailty risk.

Keyphrases

community dwelling
signaling pathway
risk assessment