Antibodies Associated With Autoimmune Encephalitis in Patients With Presumed Neurodegenerative Dementia.
Anna E M BastiaansenRobin W van SteenhovenEsmee S Te VaarwerkWiesje Maria van der FlierCharlotte E TeunissenEsther de GraaffMariska M P NagtzaamManuela PaunovicSuzanne C FrankenMarco W J SchreursFrank LeypoldtPeter A E SmittJuna M de VriesHarro SeelaarJohn van SwietenFrank Jan de JongYolande A L PijnenburgMaarten J TitulaerPublished in: Neurology(R) neuroimmunology & neuroinflammation (2023)
A small, but clinically relevant proportion of patients suspected to have neurodegenerative dementias have neuronal antibodies indicative of AIE and might benefit from immunotherapy. In patients with atypical signs for neurodegenerative diseases, clinicians should consider neuronal antibody testing. Physicians should keep in mind the clinical phenotype and confirmation of positive test results to avoid false positive results and administration of potential harmful therapy for the wrong indication.