Sex Difference in Capillary Reperfusion After Transient Middle Cerebral Artery Occlusion in Diabetic Mice.
Wenbin ZhuCatherine M DavisElyse M AllenSarah L FellerThierno M BahRobert E ShangrawRuikang K WangNabil J AlkayedPublished in: Stroke (2023)
DM2 impairs capillary perfusion and exacerbates ischemic deep brain injury in male but not female young adult mice. Premenopausal females appear to be protected against DM2-related capillary dysfunction and brain injury.
Keyphrases
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage
- middle cerebral artery
- young adults
- internal carotid artery
- oxidative stress
- glycemic control
- blood brain barrier
- acute myocardial infarction
- coronary artery disease
- high fat diet induced
- type diabetes
- ischemia reperfusion injury
- metabolic syndrome
- acute coronary syndrome