Adult-onset idiopathic dystonia: A national data-linkage study to determine epidemiological, social deprivation, and mortality characteristics.
Grace A BaileyAnna RawlingsFatemeh TorabiOwen PickrellKathryn J PeallPublished in: European journal of neurology (2021)
We have developed a case-ascertainment algorithm, supported by the introduction of a neurologist-reviewed validation cohort, providing a platform for future population-based dystonia studies. We have established robust population-level prevalence and incidence values for adult-onset idiopathic forms of dystonia, with this reflecting increasing clinical recognition and identification of causal genes. Underlying causes of death mirrored those of the general population, including circulatory disorders, respiratory disorders, cancers, and dementia.
Keyphrases
- deep brain stimulation
- early onset
- risk factors
- genome wide
- bioinformatics analysis
- mild cognitive impairment
- mental health
- machine learning
- deep learning
- quality improvement
- cardiovascular events
- electronic health record
- cognitive impairment
- high throughput
- cardiovascular disease
- type diabetes
- current status
- extracorporeal membrane oxygenation
- human immunodeficiency virus
- hiv testing
- genome wide analysis