Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel.
Isabelle A M van ThielWouter J de JongeIsaac M ChiuRene M van den WijngaardPublished in: American journal of physiology. Gastrointestinal and liver physiology (2020)
Visceral hypersensitivity of the lower gastrointestinal tract, defined as an increased response to colorectal distension, frequently prompts episodes of debilitating abdominal pain in irritable bowel syndrome (IBS). Although the pathophysiology of IBS is not yet fully elucidated, it is well known that stress is a major risk factor for development and acts as a trigger of pain sensation. Stress modulates both immune responses as well as the gut microbiota and vice versa. Additionally, either microbes themselves or through involvement of the immune system, activate or sensitize afferent nociceptors. In this paper, we review current knowledge on the influence of stress along the gut-brain-microbiota axis and exemplify relevant neuroimmune cross talk mechanisms in visceral hypersensitivity, working toward understanding how gut microbiota-neuroimmune cross talk contributes to visceral pain sensation in IBS patients.
Keyphrases
- irritable bowel syndrome
- stress induced
- insulin resistance
- chronic pain
- abdominal pain
- immune response
- end stage renal disease
- drug induced
- pain management
- neuropathic pain
- newly diagnosed
- ejection fraction
- healthcare
- chronic kidney disease
- prognostic factors
- metabolic syndrome
- peritoneal dialysis
- white matter
- adipose tissue
- patient reported outcomes
- spinal cord injury
- resting state
- functional connectivity
- blood brain barrier
- inflammatory response
- heat stress