Variant allele frequency in baseline circulating tumour DNA to measure tumour burden and to stratify outcomes in patients with RAS wild-type metastatic colorectal cancer: a translational objective of the Valentino study.
Francesco PantanoSalvatore CoralloSara LonardiGiovanni FucàAdele BusicoAlberto Giovanni LeoneFrancesca CortiCarlotta AntoniottiLetizia ProcaccioValeria SmiroldoMargherita RattiRoberto MurialdoPatrizia RaccaFilippo PaganiGiovanni RandonAntonia MartinettiElisa SottotettiMichele PrisciandaroMargherita AmbrosiniAlessandra RaimondiFederica MoranoFilippo PietrantonioPublished in: British journal of cancer (2021)
CtDNA measured by VAF is prognostic in patients with RAS wild-type mCRC. Response and PFS after an anti-EGFR-based first-line strategy are independent from initial tumour burden.