Effects of ApoE genotype on clinical phenotypes in early-onset and late-onset Alzheimer's disease in China: Data from the PUMCH dementia cohort.

Liling DongJie LiCaiyan LiuChenhui MaoJie WangDan LeiXinying HuangShanshan ChuBo HouFeng FengLongze ShaQi XuJing Gao

Published in: Brain and behavior (2021)

ApoE exerts a heterogeneous effect on clinical phenotypes in EOAD and LOAD, which might be related to the different genetic and pathological basis underlying them.

Keyphrases

early onset
late onset
cognitive decline
mild cognitive impairment
high fat diet
type diabetes
cognitive impairment
gene expression
skeletal muscle
electronic health record
metabolic syndrome
big data
dna methylation
adipose tissue
artificial intelligence