DNAzyme-Functionalized Nanomaterials: Recent Preparation, Current Applications, and Future Challenges.
Jabrane JouhaHai XiongPublished in: Small (Weinheim an der Bergstrasse, Germany) (2021)
DNAzyme-nanomaterial bioconjugates are a popular hybrid and have received major attention for diverse biomedical applications, such as bioimaging, biosensor development, cancer therapy, and drug delivery. Therefore, significant efforts are made to develop different strategies for the preparation of inorganic and organic nanoparticles (NPs) with specific morphologies and properties. DNAzymes functionalized with metal-organic frameworks (MOFs), gold nanoparticles (AuNPs), graphene oxide (GO), and molybdenum disulfide (MoS2 ) are introduced and summarized in detail in this review. Moreover, the focus is on representative examples of applications of DNAzyme-nanomaterials over recent years, especially in bioimaging, biosensing, phototherapy, and stimulation response delivery in living systems, with their several advantages and drawbacks. Finally, the perspective regarding the future directions of research addressing these challenges is also discussed and highlighted.
Keyphrases
- quantum dots
- metal organic framework
- living cells
- cancer therapy
- label free
- drug delivery
- gold nanoparticles
- molecularly imprinted
- fluorescent probe
- current status
- sensitive detection
- reduced graphene oxide
- single molecule
- water soluble
- working memory
- drug release
- quality improvement
- solid phase extraction
- high resolution