Login / Signup

Genetics of biologically based psychological differences.

Hannah M SallisGeorge Davey SmithMarcus R Munafo
Published in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences (2019)
In recent years, substantial effort has gone into disentangling the genetic contribution to individual differences in behaviour (such as personality and temperament traits). Heritability estimates from twin and family studies, and more recently using whole genome approaches, suggest a substantial genetic component to these traits. However, efforts to identify the genes that influence these traits have had relatively little success. Here, we review current work investigating the heritability of individual differences in behavioural traits and provide an overview of the results from genome-wide association analyses of these traits to date. In addition, we discuss the implications of these findings for the potential applications of Mendelian randomization.This article is part of the theme issue 'Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences'.
Keyphrases
  • genome wide
  • dna methylation
  • genome wide association
  • copy number
  • risk assessment
  • physical activity
  • case control