Arthproliferins A-D, Four New Sesterterpenes from the Mangrove-Sediment-Derived Fungus Arthrinium sp. SCSIO41221.

Bin YangCuitian LiYing ChenYanchun HeJianglian SheXue-Feng Zhou Huangming TaoBo Peng

Published in: Molecules (Basel, Switzerland) (2023)

Four new sesterterpenes, arthproliferins A-D ( 1 - 4 ), together with four known derivatives, were isolated and characterized from the mangrove-sediment-derived fungus Arthrinium sp. SCSIO41221. Their structures were determined using detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. Some of the isolated compounds were evaluated for their cytotoxicity in vitro. The results revealed that terpestacin ( 6 ) exhibited significant activity with an IC 50 value of 20.3 μM, and compounds 2 and 5 were found to show weak inhibitory effects against U87MG-derived GSCs.

Keyphrases

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mass spectrometry
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