Estimating risk of consequences following hypoglycaemia exposure using the Hypo-RESOLVE cohort: a secondary analysis of pooled data from insulin clinical trials.

Joseph C Mellor Dmitry Kuznetsov Simon R Heller Mari-Anne Gall Myriam Rosilio Stephanie A Amiel Mark Ibberson Stuart J McGurnaghan Luke A K Blackbourn William Berthon Adel Salem Yongming Qu Rory J McCrimmon Bastiaan E De Galan Ulrik Pedersen-Bjergaard Joanna Leaviss Paul M McKeigue Helen Martina Colhoun

Published in: Diabetologia (2024)

These data are consistent with hypoglycaemia being associated with an increased risk of adverse events across several body systems in diabetes. These associations are not confined to severe hypoglycaemia requiring assistance.

Keyphrases

type diabetes
clinical trial
glycemic control
electronic health record
cardiovascular disease
big data
insulin resistance
early onset
adipose tissue
phase iii
machine learning
skeletal muscle
study protocol
double blind