Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma.

Sho Sekiya Junki Fukuda Ryodai Yamamura Takako Ooshio Yusuke Satoh Shinya Kosuge Reo Sato Kanako C Hatanaka Yutaka Hatanaka Tomoko Mitsuhashi Toru Nakamura Yoshihiro Matsuno Satoshi Hirano Masahiro Sonoshita

Published in: Cancer research (2023)

Development of a Drosophila model mimicking genetic alterations in human pancreatic ductal adenocarcinoma provides a tool for genetic screening that identifies MEK and AURKB inhibition as a potential treatment strategy.

Keyphrases

genome wide
dna methylation
endothelial cells
copy number
pi k akt
induced pluripotent stem cells
cell proliferation
combination therapy
replacement therapy