Effect and mechanism of recombinant human fibroblast growth factor 18 on osteoporosis in OVX mice.

P Y LuM HuangM H ShaoJ X HuC Y DingY J FengM ZhangH P LinHaishan Tian

Published in: Climacteric : the journal of the International Menopause Society (2024)

FGF18 could effectively prevent bone loss in OVX mice by enhancing osteoblastogenesis and protecting osteoblasts from oxidative stress-induced apoptosis.

Keyphrases

induced apoptosis
oxidative stress
bone loss
recombinant human
endoplasmic reticulum stress
signaling pathway
high fat diet induced
postmenopausal women
dna damage
bone mineral density
insulin resistance
wild type
type diabetes