Imaging necrosis during treatment is associated with worse survival in EORTC 26101 study.
Martha NowosielskiThierry GorliaJacoline E C BrombergFelix SahmInga HartingPhilipp KickingerederAlba A BrandesMartin J B TaphoornWalter TaalJulien DomontAhmed IdbaihMario CamponePaul M ClementMichael WellerMichel FabbroEmilie Le RhunMichael PlattenVassilis GolfinopoulosMartin J van den BentMartin BendszusWolfgang WickPublished in: Neurology (2019)
Increase of and new development of imaging necrosis during treatment is a negative prognostic factor for patients with progressive glioblastoma. These data call for consideration of integrating the assessment of imaging necrosis as a separate item into the MRI response assessment criteria.