C-C motif chemokine ligand 5 confines liver regeneration by down-regulating reparative macrophage-derived hepatocyte growth factor in a forkhead box O 3a-dependent manner.
Miao HuangJunzhe JiaoHao CaiYichi ZhangYuhan XiaJiacheng LinZhi ShangYihan QianFang WangHailong WuXiao-Ni KongJinyang GuPublished in: Hepatology (Baltimore, Md.) (2022)
Our findings suggest that inhibition of CCL5 is a promising strategy to improve regeneration restoration by enhancing HGF secretion from reparative macrophages through the FoxO3a pathway, which may potentially reduce the mortality of PHLF.