Supplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABA.

Hao-Jie ZhongSi-Qi WangRuo-Xin ZhangYu-Pei ZhuangLongyan LiShuo-Zhao YiYing LiLei WuYu DingJumei ZhangXinqiang XieXing-Xiang HeQingping Wu

Published in: Translational neurodegeneration (2023)

These findings highlight that deficiency of GABA-producing gut microbes plays an essential role in the pathogenesis of ET and that L5 is a promising candidate for treating ET.

Keyphrases

deep brain stimulation
parkinson disease
mouse model
replacement therapy
smoking cessation