Total Syntheses and Configuration Assignments of JBIR-06 and Related Depsipeptides.

Chie HamadaYoshinosuke UsukiDaiki TakeuchiHikaru OgawaRyota AbeTetsuya Satoh

Published in: Organic letters (2019)

The first total syntheses of JBIR-06 and two analogous depsipeptides, 12-membered antimycin-class antibiotics, have been accomplished via Shiina macrolactonization. Comparison of the spectroscopic data of the synthesized compounds with those reported for natural products verified that the absolute configutation of the natural products was (2 S,4 S,6 S,7 R,14 S).

Keyphrases

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artificial intelligence