Mechanism by Which Inflammation and Oxidative Stress Induce Mineralocorticoid Receptor Gene Expression in Aging Vascular Smooth Muscle Cells.
Jaime IbarrolaQing LuMaria-Christina ZennaroIris Z JaffePublished in: Hypertension (Dallas, Tex. : 1979) (2022)
These data implicate the inflammatory TF, NFκB, and oxidative stress-induced TF, HIF1α, in regulating SMC MR transcription in aging HASMCs, which drives aging-related vascular stiffness and cardiovascular disease.
Keyphrases
- oxidative stress
- vascular smooth muscle cells
- gene expression
- cardiovascular disease
- dna damage
- ischemia reperfusion injury
- signaling pathway
- dna methylation
- induced apoptosis
- type diabetes
- electronic health record
- endothelial cells
- big data
- immune response
- lps induced
- transcription factor
- magnetic resonance imaging
- cardiovascular risk factors
- deep learning
- cell proliferation