HIV-1 genotypic resistance testing using single molecule real-time sequencing.

Stéphanie RaymondNicolas JeanneCamille VellasFlorence NicotKarine SauneNoémie RangerJustine LatourRomain CarcenacAgnès HarterPierre DelobelJacques Izopet

Published in: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (2024)

SMRT sequencing of the full-length HIV-1 polymerase appeared performant for characterizing HIV-1 genotypic resistance on both RNA and DNA clinical samples. Long-read sequencing is a new tool for mutation haplotyping and resistance analysis.

Keyphrases

single molecule
antiretroviral therapy
hiv positive
hiv testing
hiv infected
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
single cell
living cells
cell free
circulating tumor