Intravitreal bevacizumab alters type IV collagenases and exacerbates arrested alveologenesis in the neonatal rat lungs.
Arwin M ValenciaCharles L CaiJeffrey TanThomas J DugganGloria B ValenciaJacob V ArandaKay D BeharryPublished in: Experimental lung research (2017)
Avastin treatment in IH has lasting alterations in the balance between MMPs and their tissue inhibitors. These changes may lead to impaired alveologenesis and tissue damage consistent with bronchopulmonary dysplasia/chronic lung disease.