Mass spectrometry-based analysis of formalin-fixed, paraffin-embedded distal cholangiocarcinoma identifies stromal thrombospondin-2 as a potential prognostic marker.

Johannes ByrlingTheresa KristlDingyuan HuIndira PlaAniel SanchezAgata SasorRoland AnderssonGyörgy Marko-VargaBodil Andersson

Published in: Journal of translational medicine (2020)

Several proteins without prior association with distal cholangiocarcinoma biology were identified and verified as differentially expressed between distal cholangiocarcinoma and normal bile duct samples. These proteins can be further evaluated to elucidate their biomarker potential and role in distal cholangiocarcinoma carcinogenesis. Stromal thrombospondin-2 is a potential prognostic marker in distal cholangiocarcinoma.

Keyphrases

minimally invasive
mass spectrometry
bone marrow
human health
genome wide
gene expression
high resolution
ms ms
simultaneous determination