Pearls and Oy-sters: MOG-AD Meningoencephalitis with Holocord Gray Matter Predominant Myelitis.
Nathan Shmuel FarkasRachel ZolnoCristina M GaudiosoAli Y MianSoe MarPublished in: Neurology (2023)
Myelin oligodendryocyte glycoprotein antibody-associated disease (MOGAD) has been implicated in a wide range of central nervous system encephalitis and myelitis presentations. We present a previously healthy 16-year-old female who presented with acute onset headaches that rapidly progressed to encephalopathy, flaccid paraparesis, lower extremity hyperreflexia, and urinary retention. Serial MRI brain and total spine imaging demonstrated evolving diffuse supratentorial leptomeningeal enhancement and holocord gray matter restricted T2 bright lesion without enhancement. CSF was markedly inflammatory with MOG antibody positive >1:10000. The patient improved after empiric steroids, plasma exchange and IVIG.
Keyphrases
- cerebrospinal fluid
- white matter
- liver failure
- high resolution
- magnetic resonance imaging
- case report
- early onset
- contrast enhanced
- respiratory failure
- oxidative stress
- resting state
- drug induced
- aortic dissection
- multiple sclerosis
- small cell lung cancer
- urinary tract infection
- diffusion weighted imaging
- functional connectivity
- cerebral ischemia
- mass spectrometry
- photodynamic therapy
- brain injury
- fluorescence imaging