Exosomal miR-100-5p inhibits osteogenesis of hBMSCs and angiogenesis of HUVECs by suppressing the BMPR2/Smad1/5/9 signalling pathway.

Wu YangWeiwen ZhuYunfei YangMinkang GuoHusun QianWeiqian JiangYu ChenChengjie LianZijie XuHaobo BaiTingmei ChenJian Zhang

Published in: Stem cell research & therapy (2021)

The NONFH exosomal miR-100-5p can lead to NONFH-like damage by targeting BMPR2 and suppressing the BMPR2/SMAD1/5/9 signalling pathway, which may be involved in the pathophysiological mechanisms of nontraumatic osteonecrosis of the femoral head (NONFH).

Keyphrases

pulmonary arterial hypertension
epithelial mesenchymal transition
transforming growth factor
pulmonary hypertension
endothelial cells
signaling pathway
oxidative stress
vascular endothelial growth factor