Developmental origins of exceptional health and survival: A four-generation family cohort study.

Matthew Thomas KeysDorthe Almind PedersenPernille Stemann LarsenAlexander KulminskiMary F FeitosaMary WojczynskiMichael ProvinceKaare Christensen

Published in: medRxiv : the preprint server for health sciences (2024)

Descendants of longevity-enriched sibships exhibit a broad health advantage manifesting as early the perinatal period. However, this effect is strongly diluted over successive generations. Our findings suggest that exceptional health and survival may have early developmental components and implicate heritable genetic and or epigenetic factors in their specific transmission.

Keyphrases

public health
healthcare
mental health
health information
gene expression
pregnant women
health promotion
human health
genome wide
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