KCl-induced repetitive cortical spreading depression inhibiting trigeminal neuronal firing is mediated by 5-HT<sub>1B/1D</sub> and opioid receptors.

Weera SupronsinchaiJan Hoffmann Simon Akerman Peter J Goadsby

Published in: Cephalalgia : an international journal of headache (2022)

The data demonstrate that repetitive cortical spreading depression inhibits a subpopulation of dural nociceptive trigeminocervical neurons, an effect mediated by serotonin and opioid receptors. This inhibition does not involve modulation of nucleus raphe magnus neurons.

Keyphrases

chronic pain
pain management
high frequency
depressive symptoms
spinal cord
neuropathic pain
sleep quality
high glucose
diabetic rats
electronic health record
spinal cord injury
big data
oxidative stress
drug induced
brain injury
cerebral ischemia
blood brain barrier