A joint study of whole exome sequencing and structural MRI analysis in major depressive disorder.
Yamin ZhangMingli LiQiang WangJacob Shujui HsuWei DengXiaohong MaPeiyan NiLiansheng ZhaoYang TianPak Chung ShamTao LiPublished in: Psychological medicine (2019)
Both rare variants analysis and imaging-genetic analysis found evidence corresponding with the neuroinflammation and synaptic plasticity hypotheses of MDD. The mediation of IQ indicates that genetic component may act on MDD through GMV alteration and cognitive impairment.