Benzene C-H Etherification via Photocatalytic Hydrogen-Evolution Cross-Coupling Reaction.
Yi-Wen ZhengPan YeBin ChenQing-Yuan MengKe FengWen-Guang WangLi-Zhu WuChen-Ho TungPublished in: Organic letters (2017)
Aryl ethers can be constructed from the direct coupling between the benzene C-H bond and the alcohol O-H bond with the evolution of hydrogen via the synergistic merger of photocatalysis and cobalt catalysis. Utilizing the dual catalyst system consisting of 3-cyano-1-methylquinolinum photocatalyst and cobaloxime, intermolecular etherification of arenes with various alcohols and intramolecular alkoxylation of 3-phenylpropanols with formation of chromanes are accomplished. These reactions proceed at remarkably mild conditions, and the sole byproduct is equivalent hydrogen gas.