Efficacy of cumulative cisplatin dose on survival in patients with locally advanced cervical cancer treated with definitive chemoradiotherapy: multicenter study by Turkish Oncology Group.

Arif Akyildiz Melis Gultekin Ecem Yigit Ecem Demir Rashad Ismayilov Melin Aydan Ahmed Mustafa Buyukkor Hasan Cagrı Yıldırım Nilgun Yıldırım Gokhan Ucar Efnan Algin Ahmet Emin Ozturk Sinem Akbas Fatih Selcukbiricik Seval Orman Nedim Turan Mesut Yilmaz Rumeysa Colak Esra Ozen Engin Nargiz Majidova Ibrahim Vedat Bayoglu Havva Beyaz Ozturk Ates Kamuran Ibıs Sefika Arzu Ergen Sezin Yuce Sari Yilmaz Tezcan Ferah Yildiz Zafer Arik

Published in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2024)

Our study showed that a cumulative cisplatin dose >200 mg, particularly in patients with lymph node metastases, significantly improved overall survival. Factors such as anemia, toxicity related challenges, and comorbidities were identified as critical considerations in treatment planning. These findings emphasize the balance between maximizing therapeutic efficacy and managing toxicity, guiding personalized treatment approaches for locally advanced cervical cancer.

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