A familiar study on self-limited childhood epilepsy patients using hIPSC-derived neurons shows a bias towards immaturity at the morphological, electrophysiological and gene expression levels.
Mariana L CasaliaJuan Cruz CasabonaCorina GarcíaVerónica Cavaliere CandedoHéctor Ramiro QuintáMaría Isabel FaríasJoaquín GonzalezDolores Gonzalez MorónMarta CórdobaDamian ConsalvoGustavo MostoslavskyFrancisco J UrbanoJuana PasquiniMario Gustavo MurerLorena RelaMarcelo A KauffmanFernando Juan PitossiPublished in: Stem cell research & therapy (2021)
We are reporting the first in vitro model of self-limited childhood epilepsy, providing the cellular bases for future in-depth studies to understand its pathogenesis. Our results show patient-specific neuronal features reflecting immaturity, in resonance with the course of the disease and previous imaging studies.
Keyphrases
- mass spectrometry
- high resolution
- gene expression
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- case control
- peritoneal dialysis
- dna methylation
- early life
- spinal cord
- prognostic factors
- current status
- emergency department
- patient reported outcomes
- young adults
- childhood cancer
- brain injury
- energy transfer